(a) Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, characterized by a multitude of autoantibody production, complement activation and immune-complex deposition, which causes tissue and organ damage. In other words, SLE (or lupus) is an autoimmune disease of the body's connective tissues.
SLE sufferers can experience rashes which are red, itchy and painful and can show up on any part of the body. The most common one is the butterfly rash as seen in Michelle's post. They are sensitive to sunlight and a short period of exposure might cause them to develop a painful rash.
Joint pain or inflammation would be evident in SLE patients. The more common spots are hands, wrists and knees. The pain can be acute or chronic. It may also cause muscle swelling.
SLE can cause headaches, seizures, abnormal blood vessels in the head, and many other problems with the nervous system. SLE can also cause organic brain syndrome. This disorder involves serious problems with memory and concentration, emotional problems, and severe agitation and hallucinations.
SLE also causes inflammation to the internal organs' membranes.
The digestive system of SLE sufferers may experience abdominal pain, loss of appetite, nausea, and sometimes vomiting.
Diagram showing the summary of the factors known to contribute to abnormal lipid profiles in SLE
SLE can cause many lung problems like inflammation of the lungs, a hemorrhage (burst blood vessel) occuring in the lungs, blood clot forming in the artery going to the lungs, blood vessels in the lungs begin to contract and a shrinking lung which decreases lung capacity.
SLE causes very low levels of red and white cells in your blood which can lead to anemia.
In the cases of pregnant women who are suffering from SLE, the chances of miscarriage, premature birth, and death of the baby in the uterus are high.
Diagram illustrating osteonecrosis in the late stages of SLE
In its late stages, SLE can also cause areas of bone tissue to die, called osteonecrosis. Osteonecrosis can cause serious disability. It can be caused at least in part by using high doses of corticosteroids over a prolonged period of long time.
Source: http://www.eorthopod.com/public/patient_education/6590/systemic_lupus_erythematosus.html
Diagram illustrating osteonecrosis in the late stages of SLEIn its late stages, SLE can also cause areas of bone tissue to die, called osteonecrosis. Osteonecrosis can cause serious disability. It can be caused at least in part by using high doses of corticosteroids over a prolonged period of long time.
Source: http://www.eorthopod.com/public/patient_education/6590/systemic_lupus_erythematosus.html
By: Eveleen
.JPG)
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