(b) Type 1 diabetes, or Insulin Dependent Diabetes Mellitus (IDDM), is a disease characterized by “auto-destruction” of the pancreatic beta cells that produce insulin. Overtime, the body silently destroys these cells creating an insulin deficiency.
Diagram showing insulin producing cells destroyed
IDDM appears to stem from an inherited defect in the immune system, triggered by some environmental stimuli.
Diagram showing insulin producing cells destroyedIDDM appears to stem from an inherited defect in the immune system, triggered by some environmental stimuli.
The exact cause of the disease is still unknown but a study found that genetic predisposition, autoimmunity, and viral infection are the main etiological factors implicated in the pathogenesis of type 1 diabetes mellitus.
Many of the patients with type 1 DM have associated autoimmune diseases like thyroid disorders, autoimmune adrenal disorders, celiac disease and connective tissue disorders, e.g. systemic lupus erythematosus (SLE).
Muthukrishnan J, Kiranmayi L, Verma A, Modi KD. Type 1 diabetes mellitus: Correlation between etiological factors and associated conditions. Int J Diab Dev Ctries [serial online] 2007 [cited 2009 Feb 8];27:46-9. Available from: http://www.ijddc.com/text.asp?2007/27/2/46/37034
By: Eveleen
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